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Initiate an alert/notification from an event/action in an iframe

It is very possibly that I am searching the forum incorrectly or not looking at the right place within the documentation. I’m trying to determine if it’s feasible to initiate and alert/notification within my application from an event or action contained in an ifame?. Creating a notification in the iframe is obviously straightforward. I am striving for consistency so that all alerts/notifications within the application are similar.