And if so, in what context?
When you make changes on page load for something and the thing hasn’t even loaded yet because privacy rules are being in the middle of being checked 
Quick question: is your app multi-user, and is there any chance two or more users would be altering the same “thing” at the same time?
Typically, there is not a huge problem if one user is (for example) setting an order’s expected delivery date and another user setting the same order’s ship-to address.
But you may have times when one person is trying to alter a delivery date, but someone else (who just got a phone call to cancel the order) is in the process of deleting the order.
IMHO, it may be helpful to test for the existence of a thing before changing it IF you think there is any possibility that the thing may be deleted at the same time someone else is trying to update it.
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